Holders AZ Alkmaar and 18-time winners Ajax survived scares to progress in the KNVB Beker with 4-1 and 4-2 wins.
PSV Eindhoven slipped to their first Eredivisie defeat of the season at AZ Alkmaar, while Ajax thrashed Go Ahead Eagles.
PSV Eindhoven stunned Ajax as they routed the defending champions 4-0 to climb to the top of the Eredivisie standings.
Ajax inflicted a first defeat on Eredivisie leaders PEC Zwolle on Saturday, while FC Twente held PSV Eindhoven.
PEC Zwolle face the stiffest test of their season as they visit reigning Eredivisie champions Ajax on Saturday.
PEC Zwolle's 100 per cent winning start to the Eredivisie season ended after they drew 1-1 at home to FC Utrecht.
Marco van Basten will put his past with Ajax to one side when the champions visit the Abe Lenstra Stadion.
Three second-half goals saw PSV Eindhoven defeat Go Ahead Eagles and make it a hat-trick of wins in the Eredivisie.
Feyenoord will do everything possible to make sure Samuel Armenteros is available for their Eredivisie clash with Ajax.
PSV beat NEC Nijmegen 5-0 while Heracles lost 3-1 at home to PEC Zwolle.
Ajax's Viktor Fischer is delighted at the way the Eredivisie champions' coach Frank de Boer encourages him to play.
Feyenoord lose 2-1 at PEC Zwolle while Vitesse Arnhem win 3-1 against Heracles Almelo .
Ajax rounded off their title-winning season with a 2-0 win at FC Groningen on Sunday.
The Eredivisie season wraps up this weekend with European issues still to be resolved.
Ajax wrapped up their third consecutive Dutch Eredivisie title in style with a 5-0 thrashing of lowly Willem II.
Former Ajax midfielder Theo Janssen has hailed the Amsterdammers as they prepare for an Eredivisie title party.
Feyenoord hit Heracles Almelo for six to keep their Eredivisie title hopes alive, while Vitesse Arnhem beat Willem II.
Ajax's Christian Eriksen won't discuss his future until the Dutch season has finished.
Feyenoord maintained their Eredivisie title hopes by beating Vitesse on Sunday, while Zwolle and Utrecht also won.
Ajax will hope to take another step towards retaining their Eredivisie title when they host Heerenveen on Friday.